Revisão Revisado por pares

Impact of Surgical Margin Width on Recurrence and Overall Survival Following R0 Hepatic Resection of Colorectal Metastases

2017; Lippincott Williams & Wilkins; Volume: 267; Issue: 6 Linguagem: Inglês

10.1097/sla.0000000000002552

ISSN

1528-1140

Autores

Georgios Antonios Margonis, Theodoros Ν. Sergentanis, Ioannis Ntanasis‐Stathopoulos, Nikolaos Andreatos, Ioannis‐Georgios Tzanninis, Kazunari Sasaki, Θεοδώρα Ψαλτοπούλου, Jane Wang, Stefan Buettner, Αpostolos Papalois, Jin He, Christopher L. Wolfgang, Timothy M. Pawlik, Matthew J. Weiss,

Tópico(s)

Hepatocellular Carcinoma Treatment and Prognosis

Resumo

To examine the impact of surgical margin width on survival following R0 hepatic resection for colorectal metastases (CRLM).Although negative resection margin is considered of paramount importance for the prognosis of patients with colorectal liver metastases, optimal resection margin width remains controversial.Eligible studies examining the association between margin status after R0 hepatic resection for CRLM and survival, including overall survival (OS) and disease-free survival (DFS) were sought using the Medline, Cochrane, and EMBASE databases. Random-effects models were used for the calculation of pooled relative risks (RRs) with their 95% confidence intervals (95% CIs).Thirty-four studies were deemed eligible for inclusion representing a cohort of 11,147 hepatic resections. Wider resection margin (>1 vs 1 cm resection margin at 3, 5, and 10 years. Interestingly, >1 mm (vs 1 mm margin is associated with better prognosis than a submillimeter margin, achieving a margin >1 cm may result in even better oncologic outcomes and should be considered if possible.

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