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Patterns and predictors of skin score change in early diffuse systemic sclerosis from the European Scleroderma Observational Study

2018; BMJ; Volume: 77; Issue: 4 Linguagem: Inglês

10.1136/annrheumdis-2017-211912

1468-2060

Ariane L. Herrick, Sébastien Peytrignet, Mark Lunt, Xiaoyan Pan, Roger Hesselstrand, Luc Mouthon, Alan J. Silman, Graham Dinsdale, Edith Brown, László Czirják, Jörg H W Distler, Oliver Distler, Kim Fligelstone, William J Gregory, Rachel Ochiel, Madelon C Vonk, Codrina Ancuţa, Voon H Ong, Dominique Farge, Marie Hudson, Marco Matucci-Cerinic, Alexandra Balbir‐Gurman, Øyvind Midtvedt, Paresh Jobanputra, Alison Jordan, Wendy Stevens, Pia Moinzadeh, Frances Hall, C. Agard, Marina Anderson, Élisabeth Diot, Rajan Madhok, Mohammed Akil, Maya H Buch, Leland W.K. Chung, Nemanja Damjanov, Harsha Gunawardena, Peter Lanyon, Yasmeen Ahmad, Kuntal Chakravarty, Søren Jacobsen, Alex J. MacGregor, Neil McHugh, Ulf Müller-Ladner, Gabriela Riemekasten, Michael Becker, Janet Roddy, Patrícia Carreira, Anne Laure Fauchais, É. Hachulla, J. Hamilton, Murat İnanç, John S McLaren, Jacob M. van Laar, Sanjay Pathare, Susanna Proudman, Anna Rudin, Joanne Sahhar, B. Coppéré, J. Serratrice, Tom Sheeran, Douglas J. Veale, C. Grangé, Georges-Selim Trad, Christopher P Denton,

Dermatologic Treatments and Research

Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosis (dcSSc) with progressive skin thickness, and (2) derive prediction models for progression over 12 months, to inform future randomised controlled trials (RCTs).