Tissue persistence of gentamicin in man
1977; American Medical Association; Volume: 238; Issue: 4 Linguagem: Inglês
10.1001/jama.238.4.327
ISSN1538-3598
Autores Tópico(s)Metabolism and Genetic Disorders
ResumoA two-compartment pharmacokinetic model was used to characterize serum concentrations and to predict tissue accumulation of gentamicin in 47 treated patients. Postmortem tissues were obtained in six cases; in each instance, tissues yielded the predicted amount of drug. Slow release of tissue-bound gentamicin accounts for its prolonged retention in the body. The two-compartment model adequately predicts gentamicin accumulation from serum concentrations and explains why this antibiotic persists in serum and urine. ( JAMA 238:327-329, 1977)
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