Progressive DNA and RNA damage from oxidation after aneurysmal subarachnoid haemorrhage in humans
2017; Taylor & Francis; Volume: 52; Issue: 1 Linguagem: Inglês
10.1080/10715762.2017.1407413
ISSN1071-5762
AutoresAnders Jørgensen, Jonatan M. Staalsoe, Anja Hviid Simonsen, Steen Gregers Hasselbalch, Peter Høgh, Allan Weimann, Henrik E. Poulsen, N.V. Olsen,
Tópico(s)Intracerebral and Subarachnoid Hemorrhage Research
ResumoFree radical toxicity is considered as a key mechanism in the neuronal damage occurring after aneurysmal subarachnoid haemorrhage (SAH). We measured markers of DNA and RNA damage from oxidation (8-oxodG and 8-oxoGuo, respectively) in cerebrospinal fluid from 45 patients with SAH on day 1-14 after ictus and 45 age-matched healthy control subjects. At baseline, both markers were significantly increased in patients compared to controls (p values < .001), and exhibited a progressive further increase (to >20-fold above control levels) from day 5-14. None of the markers predicted the occurrence of vasospasms or mortality, although there was a trend that the 8-oxoGuo marker was more strongly associated with mortality than the 8-oxodG marker. We conclude that SAH leads to a massive increase in damage to nucleic acids from oxidative stress, which is likely to play a role in neuronal dysfunction and death. As only patients in need of a ventriculostomy catheter were included in the study, the findings cannot necessarily be extrapolated to all patients with SAH.
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