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Baccharis reticularia DC. and Limonene Nanoemulsions: Promising Larvicidal Agents for Aedes aegypti (Diptera: Culicidae) Control

2017; Multidisciplinary Digital Publishing Institute; Volume: 22; Issue: 11 Linguagem: Inglês

10.3390/molecules22111990

ISSN

1433-1373

Autores

Gisele da S. Botas, Rodrigo Alves Soares Cruz, Fernanda Almeida, Jonatas Lobato Duarte, Raquel Silva Araújo, Raimundo Nonato Picanço Souto, Ricardo Marcelo dos Anjos Ferreira, José Carlos Tavares Carvalho, Marcelo Guerra Santos, Leandro Rocha, Vera L. P. Pereira, Caio P. Fernandes,

Tópico(s)

Allelopathy and phytotoxic interactions

Resumo

Baccharis reticularia DC. is a plant species from the Asteraceae family that is endemic to Brazil. Despite the great importance of Baccharis genus, no study has been carried out regarding either the phytochemical composition of B. reticularia or the evaluation of its larvicidal potential. Considering the intrinsic immiscibility of essential oils, this study shows larvicidal nanoemulsions containing the B. reticularia phytochemically characterized essential oil and its main constituent against Aedes aegypti. The major compound found was d-limonene (25.7%). The essential oil inhibited the acetylcholinesterase, one of the main targets of insecticides. The required hydrophile-lipophile balance of both nanoemulsions was 15.0. The mean droplet sizes were around 90.0 nm, and no major alterations were observed after 24 h of preparation for both formulations. After 48 h of treatment, the estimated LC50 values were 118.94 μg mL−1 and 81.19 μg mL−1 for B. reticularia essential oil and d-limonene nanoemulsions, respectively. Morphological alterations evidenced by scanning electron micrography were observed on the larvae treated with the d-limonene nanoemulsion. This paper demonstrated a simple and ecofriendly method for obtaining B. reticularia essential oil and d-limonene aqueous nanoemulsions by a non-heating and solvent-free method, as promising alternatives for Aedes aegypti control.

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