Scalable Electrochemical Dehydrogenative Lactonization of C(sp 2 /sp 3 )–H Bonds
2017; American Chemical Society; Volume: 20; Issue: 1 Linguagem: Inglês
10.1021/acs.orglett.7b03617
ISSN1523-7060
AutoresSheng Zhang, Lijun Li, Huiqiao Wang, Qian Li, Wenmin Liu, Kun Xu, Cheng‐Chu Zeng,
Tópico(s)Oxidative Organic Chemistry Reactions
ResumoA practical, electrochemical method is developed for the direct dehydrogenative lactonization of C(sp2/sp3)–H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature of this newly developed electrochemical process was demonstrated on a 40 g scale following an operationally simple protocol. The remote lactonization of C(sp3)–H bonds would constitute an important synthetic advance toward electrochemical C–O bond formation.
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