Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells
2017; Elsevier BV; Volume: 143; Linguagem: Inglês
10.1016/j.ejmech.2017.11.059
ISSN1768-3254
AutoresRicardo G. Teixeira, Ana Rita Brás, Leonor Côrte‐Real, Rajendhraprasad Tatikonda, Anabela Sanches, M. Paula Robalo, Fernando Avecilla, Tiago Moreira, M. Helena García, Matti Haukka, Ana Preto, Andreia Valente,
Tópico(s)Ferrocene Chemistry and Applications
ResumoThree new compounds have been synthesized and completely characterized by analytical and spectroscopic techniques. The new bipyridine-perfluorinated ligand L1 and the new organometallic complex [Ru(η5-MeCp)(PPh3)2Cl] (Ru1) crystalize in the centrosymmetric triclinic space group P1¯. Analysis of the phenotypic effects induced by both organometallic complexes Ru1 and [Ru(η5-MeCp)(PPh3)(L1)][CF3SO3] (Ru2), on human colorectal cancer cells (SW480 and RKO) survival, showed that Ru2 has a potent anti-proliferative activity, 4-6 times higher than cisplatin, and induce apoptosis in these cells. Data obtained in a noncancerous cell line derived from normal colon epithelial cells (NCM460) revealed an intrinsic selectivity of Ru2 for malignant cells at low concentrations, showing the high potential of this compound as a selective anticancer agent.
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