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Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer’s Disease

2017; Elsevier BV; Volume: 3; Issue: 5 Linguagem: Inglês

10.1016/j.bpsc.2017.11.012

2451-9030

Sander C.J. Verfaillie, Alexa Pichet Binette, Étienne Vachon‐Presseau, Shirin Tabrizi, Mélissa Savard, Pierre Bellec, Rik Ossenkoppele, Philip Scheltens, Wiesje M. van der Flier, John C.S. Breitner, Sylvia Villeneuve, Paul Aisen, Elena Anthal, Melissa Appleby, Gülebru Ayrancı, Alan Barkun, Thomas Beaudry, Pierre Bellec, Fatiha Benbouhoud, Véronique D. Bohbot, Jason Brandt, John C.S. Breitner, Leopoldina Carmo, Edouard Carrier Charles, M. Mallar Chakravarty, Laksanun Cheewakriengkrai, D. Louis Collins, Blandine Courcot, Doris Couture, Suzanne Craft, A. Claudio Cuello, Mahsa Dadar, Christian Dansereau, DasSamir, Marina Dauar-Tedeschi, Doris Dea, Clément Debacker, René Désautels, Sylvie Dubuc, Guerda Duclair, Marianne Dufour, Mark Eisenberg, Rana El-Khoury, Pierre Étienne, Alan C. Evans, Anne-Marie Faubert, Fabiola Ferdinand, Vladimir Fonov, David Fontaine, Josée Frappier, Joanne Frenette, Guylaine Gagné, Serge Gauthier, Valérie Gervais, Renuka Giles, Julie Gonneaud, Renee Gordon, Rick Hoge, Bradley T. Hyman, Yasser Ituria-Medina, Clifford R. Jack, Justin Kat, Christina Kazazian, Zaven S. Khachaturian, David S. Knopman, Penelope Kostopoulos, Anne Labonté, Marie‐Élyse Lafaille‐Magnan, Tanya Lee, Jeannie‐Marie Leoutsakos, Claude Lepage, Illana Leppert, Cécile Madjar, Laura Mahar, David Maillet, Jean-Robert Maltais, Axel Mathieu, Sulantha Mathotaarachchi, Gerhard Maultaup, Ginette Mayrand, Pierre‐François Meyer, Diane Michaud, Justin Miron, Thomas J. Montine, John C. Morris, Lisa Marie Munter, Vasavan Nair, Jamie Near, Holly Newbold-Fox, Pierre Orban, Véronique Pagé, Tharick A. Pascoal, Mirela Petkova, Cynthia Picard, Alexa Pichet Binette, Galina Pogossova, Judes Poirier, Jens C. Pruessner, Natasha Rajah, Pierre Rioux, Pedro Rosa‐Neto, Mark A. Sager, Eunice Farah Saint-Fort, Mélissa Savard, Reisa Sperling, Shirin Tabrizi, Angela Tam, Christine L. Tardif, Pierre N. Tariot, Eduard Teigner, Louise Théroux, Ronald G. Thomas, Paule‐Joanne Toussaint, Jennifer Tremblay‐Mercier, Miranda Tuwaig, Isabelle Vallée, Vinod Venugopalan, Sander C.J. Verfaillie, Sylvia Villeneuve, Jacob W. Vogel, Karen Wan, Seqian Wang, Elsa Yu,

Mental Health Research Topics

Both subjective cognitive decline (SCD) and a family history of Alzheimer's disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD. We studied 124 asymptomatic individuals with a family history of AD (age 64 ± 5 years). Participants were categorized as having SCD if they reported that their memory was becoming worse (SCD+). We used extensive neuropsychological assessment to investigate five different cognitive domain performances at baseline (n = 124) and 1 year later (n = 59). We assessed interconnectivity among three a priori defined ROIs: pDMN, anterior ventral DMN, medial temporal memory system (MTMS), and the connectivity of each with the rest of brain. Sixty-eight (55%) participants reported SCD. Baseline cognitive performance was comparable between groups (all false discovery rate-adjusted p values > .05). At follow-up, immediate and delayed memory improved across groups, but the improvement in immediate memory was reduced in SCD+ compared with SCD− (all false discovery rate–adjusted p values < .05). When compared with SCD−, SCD+ subjects showed increased pDMN–MTMS connectivity (false discovery rate–adjusted p < .05). Higher connectivity between the MTMS and the rest of the brain was associated with better baseline immediate memory, attention, and global cognition, whereas higher MTMS and pDMN–MTMS connectivity were associated with lower immediate memory over time (all false discovery rate–adjusted p values < .05). SCD in cognitively normal individuals is associated with diminished immediate memory practice effects and a brain connectivity pattern that mirrors early AD-related connectivity failure.