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BIBTEX RIS

Breath Volatile Organic Compound Profiling of Colorectal Cancer Using Selected Ion Flow-tube Mass Spectrometry

2017; Lippincott Williams & Wilkins; Volume: 269; Issue: 5 Linguagem: Inglês

10.1097/sla.0000000000002539

ISSN

1528-1140

Autores

Sheraz R. Markar, Sung‐Tong Chin, Andrea Romano, Tom Wiggins, Stefan Antonowicz, Paraskevas Paraskeva, Paul Ziprin, Ara Darzi, George B. Hanna,

Tópico(s)

Analytical Chemistry and Chromatography

Resumo

BACKGROUND:: Breath VOCs have the potential to noninvasively diagnose cancer.Exhaled breath samples were collected using 2-L double-layered Nalophan bags, and were analyzed using selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy for luminal inspection and computed tomography (CT) to confirm cancer recurrence. Three studies were conducted: RESULTS:: CONCLUSION:: This study suggests the association of a single breath biomarker with the primary presence and recurrence of CRCa. Further multicenter validation studies are required to validate these findings.

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