A Milestone for CAR T Cells
2017; Massachusetts Medical Society; Volume: 377; Issue: 26 Linguagem: Inglês
10.1056/nejme1714680
ISSN1533-4406
AutoresEric Tran, Dan L. Longo, Walter J. Urba,
Tópico(s)Virus-based gene therapy research
ResumoMore than 7 years have passed since the regression of advanced lymphoma was first reported in a patient who had undergone the infusion of T cells engineered to express a chimeric antigen receptor (CAR) targeting the CD19 antigen expressed on the surface of both normal and malignant B cells.1 Subsequent trials of CD19-targeted CAR T-cell therapy showed a complete response in some patients with relapsed or chemotherapy-refractory hematologic cancers for which there were no effective therapies.2-5 This personalized therapeutic approach entails the removal of peripheral-blood T cells from a patient, followed by in vitro activation, genetic modification, and expansion of . . .
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