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Somatic Development in Children with Congenital Heart Defects

2017; Elsevier BV; Volume: 192; Linguagem: Inglês

10.1016/j.jpeds.2017.09.059

1097-6833

Martin Poryo, Laura Antonia Paes, Thomas Pickardt, Ulrike Bauer, Sascha Meyer, Stefan Wagenpfeil, Hashim Abdul‐Khaliq, Gunter Kerst, Jaime F. Vázquez-Jiménez, Dimitrios Gkalpakiotis, Andrea Schedifka, G. Buheitel, Joachim Streble, Deniz Kececioglu, Eugen Sandica, Burkhard Trusen, Felix Berger, Oliver Miera, Stanislav Ovroutski, Björn Peters, Katharina Schmitt, Stephan Schubert, Joachim Photiadis, Felix Berger, Bernd Opgen‐Rhein, Katja Weiß, Christoph Berns, Carl-Christian Blumenthal-Barby, Thomas P. Van Boeckel, Susanne Krusche, Jürgen Busse, Andreas Kästner, Heike Koch, Christian Köpcke, Frank Streichan, Jens Timme, Birgit Franzbach, Gabriela Senft, Frank Beyer, Klaus Winter, Judith Breuer, Armin Welz, J. Bahlmann, Eberhard Griese, Trong Phi Lê, Joachim Hebe, Jan‐Hendrik Nürnberg, Annette Magsaam, Ronald Müller, Ludger Potthoff, R Voigt, Timothy Krüger, Hubert Gerleve, Ulrich Kleideiter, Dirk Schneider‐Kulla, E Feil, Thomas Menke, Martin Lehn, Martina Grohmann, Helge Tomczak, Otto N. Krogmann, G. Tarusinov, Michael Scheld, Ertan Mayatepek, Frank Pillekamp, Artur Lichtenberg, Christiane Terpeluk, Veronika von Jan, Sven Dittrich, Ulrike Gundlach, Robert Cesnjevar, Ulrich Neudorf, G Morf, Anoosh Esmaeili, Stephan Backhoff, Brigitte Stiller, Friedhelm Beyersdorf, Johannes Kroll, A. Wildberg, Jannos Siaplaouras, Antje Masri‐Zada, Christian Jux, Andreas Böning, Hakan Akintürk, Thomas Paul, Theodor Tirilomis, G Schürer, Johannes Hartmann, Ralph Grabitz, Uta Liebaug, Claudius Rotzsch, Rainer Kozlik‐Feldmann, Jörg S. Sachweh, Arlindo Riso, Volker Petersen, Bernd Friedrich, Otmar Schlobohm, Philipp Beerbaum, Dietmar Böthig, Alexander Horke, Johann Bauersachs, Mechthild Westhoff‐Bleck, Matthias Gorenflo, Matthias Karck, Tsvetomir Loukanov, Christian Sebening, Hermann Schrüfer, Martin Wilken, Hashim Abdul‐Khaliq, Tanja Rädle‐Hurst, Axel Rentzsch, Hans‐Joachim Schäfers, Hagen Reichert, Thomas Kriebel, Arnulf Boysen, Hans‐Heiner Kramer, J Cremer, Jens Scheewe, Regina Buchholz‐Berdau, Peter Möller, Wolfgang Ram, Konrad Brockmeier, Gerardus B.W.E. Bennink, A. Gillor, Tim Niehues, Peter Terhoeven, Steffen Leidig, Ingo Dähnert, P Kinzel, Martin Kostelka, Liane Kändler, Martin Bethge, Stefan Köster, Christoph Schröder, Jens Karstedt, Uwe Seitz, Christoph Kampmann, Christian‐Friedrich Vahl, Frank Stahl, Helmut Barth, Joachim Müller‐Scholden, Peter Ewert, Alfred Hager, Harald Kaemmerer, Nicole Nagdyman, Jörg Schoetzau, Oktay Tutarel, Rüdiger Lange, Nikolaus A. Haas, Lale Hakami, Michael Hauser, Alexander Roithmaier, Hans-Gerd Kehl, Edward Malec, Helmut Baumgartner, Gerhard‐Paul Diller, Roswitha Bahle, Gerald Hofner, Stefan Zink, R Reif, Christoph Parlasca, Matthias W. Freund, Michaël Schumacher, Christine Darrelmann, Reinald Motz, Olaf Willmann, Norbert Schmiedl, Peter Quick, Dirk Hillebrand, Petra Hirsemann, Stephan Michele Eiselt, Torsten Nekarda, Michael Eberhard, Martin Schneider, Boulos Asfour, Georg Baier, Frank Uhlemann, Michael Scheid, Alexander Beyer, Gudrun Binz, Thomas Teufel, Ronald-Peter Handke, Michael Hofbeck, Renate Kaulitz, Ludger Sieverding, Christian Schlensak, Christian Apitz, Christoph Kupferschmid, Jürgen Holtvogt, Carl‐Friedrich Wippermann, Andreas Heusch, Johannes Wirbelauer, Wolfgang Brosi,

Cardiovascular Conditions and Treatments

ObjectivesSomatic development is impaired in children with congenital heart defects (CHDs), and head circumference seems to be a strong predictor of neurodevelopmental prognosis. The aim of this study was to generate up-to-date reference values for the somatic development (head circumference, body weight, and length/height) of children with CHDs.Study designOur study population consisted of all patients included in the PAN study (Prävalenz angeborener Herzfehler bei Neugeborenen in Deutschland), which was conducted prospectively over a 3-year study period by the Competence Network for Congenital Heart Defects. All children with mild, moderate, and severe CHDs born in 2006-2009 in Germany were enrolled. For computing of z-scores, only children with the following characteristics were included: appropriate for gestational age, nonsyndromic disease, term or post-term delivery, and no cardiac surgery.ResultsThere were 2818 patients included. New z-scores for the described somatic measures of children with mild, moderate, and severe CHDs were computed. Comparisons with the KiGGS study (Gesundheit von Kindern und Jugendlichen in Deutschland) and the Berlin Longitudinal Study revealed significantly lower measurements for all measures—most notably in children with severe CHDs and/or cardiac surgery. In our cohort, no catch-up growth was seen after cardiac surgery.ConclusionChildren with severe CHDs demonstrated the most abnormal pattern in growth, including head circumference before and after cardiac surgery, which is indicative of accompanying brain pathology unrelated to operative injury.