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Doxycycline post-exposure prophylaxis: let the debate begin

2017; Elsevier BV; Volume: 18; Issue: 3 Linguagem: Inglês

10.1016/s1473-3099(17)30726-0

1474-4457

Christopher K. Fairley, Eric P. F. Chow,

HIV/AIDS Research and Interventions

Should physicians prescribe doxycycline to prevent syphilis? In their study published in The Lancet Infectious Diseases, Jean-Michel Molina and colleagues 1 Molina JM Charreau I Chidiac C et al. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis. 2017; (published online Dec 8.)http://dx.doi.org/10.1016/S1473-3099(17)30725-9 Summary Full Text Full Text PDF PubMed Scopus (95) Google Scholar report on the findings of the first large, open-label randomised control trial to help answer this question. 2 Bolan RK Beymer MR Weiss RE Flynn RP Leibowitz AA Klausner JD Doxycycline prophylaxis to reduce incident syphilis among HIV-infected men who have sex with men who continue to engage in high-risk sex: a randomized, controlled pilot study. Sex Transm Dis. 2015; 42: 98-103 Crossref PubMed Scopus (87) Google Scholar Their findings show that, among men who have sex with men (MSM) who were using pre-exposure prophylaxis (PrEP) for HIV and who had a median of ten partners every 2 months, taking doxycycline within 24 h after sex reduced the incidence of chlamydia by 70% when compared with no prophylaxis (hazard ratio [HR] 0·30, 95% CI 0·13–0·70; p=0·006); similar results were observed for syphilis (0·27, 0·07–0·98; p=0·047), but not for gonorrhoea (0·83, 0·47–1·47; p=0·52). 1 Molina JM Charreau I Chidiac C et al. Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial. Lancet Infect Dis. 2017; (published online Dec 8.)http://dx.doi.org/10.1016/S1473-3099(17)30725-9 Summary Full Text Full Text PDF PubMed Scopus (95) Google Scholar Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trialDoxycycline PEP reduced the occurrence of a first episode of bacterial STI in high-risk men who have sex with men. Full-Text PDF