Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Myrtenol protects against myocardial ischemia-reperfusion injury through antioxidant and anti-apoptotic dependent mechanisms

2017; Elsevier BV; Volume: 111; Linguagem: Inglês

10.1016/j.fct.2017.12.003

ISSN

1873-6351

Autores

Raquel Moreira de Britto, Júlio Alves da Silva-Neto, Thássio Mesquita, Carla Maria Lins de Vasconcelos, Grace Kelly Melo de Almeida, Itamar Couto Guedes de Jesus, Péligris Henrique dos Santos, Diego Santos Souza, Rodrigo Miguel‐dos‐Santos, Lucas Andrade de Sá, Fanildes Silva Moraes dos Santos, Rose Nely Pereira‐Filho, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Lucindo José Quintans‐Júnior, Sílvia Guatimosim, Sandra Lauton‐Santos,

Tópico(s)

Cardiac electrophysiology and arrhythmias

Resumo

Myrtenol is a monoterpene with multiple pharmacological activities. However, although monoterpenes have been proposed to play beneficial roles in a variety of cardiac disorders, pharmacological actions of myrtenol in the heart are not yet reported. Hence, the aim of this study was to evaluate whether myrtenol promotes cardioprotection against myocardial ischemia-reperfusion (IR) injury, and the mechanisms involved in these effects. Male Wistar rats were orally treated for seven consecutive days with myrtenol (50 mg/kg) or N-acetyl cysteine (1.200 mg/kg, NAC). Afterward, hearts were subjected to myocardial IR injury. Here, we show that the severe impairment of contractile performance induced by IR was significantly prevented by myrtenol or NAC. Moreover, myrtenol abolished aberrant electrocardiographic waveform (ST-segment elevation), as well as reduced life-threatening arrhythmias and infarct size induced by IR injury. Importantly, myrtenol fully prevented the massive increase of cardiac reactive oxygen species generation and oxidative stress damage. Accordingly, myrtenol restored the impairment of endogenous antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase and reductase) activities and balance of pro- and anti-apoptotic pathways (Bax and Bcl-2), associated with decreased apoptotic cells. Taken together, our data show that myrtenol promotes cardioprotection against IR injury through attenuation of oxidative stress and inhibition of pro-apoptotic pathway.

Referência(s)