Evaluation of antibacterial and modifying action of catechin antibiotics in resistant strains
2017; Elsevier BV; Volume: 115; Linguagem: Inglês
10.1016/j.micpath.2017.12.058
ISSN1096-1208
AutoresFernanda Mateus Silva Gomes, Jayze da Cunha Xavier, Joycy Francely Sampaio dos Santos, Yedda Maria Lobo Soares de Matos, Saulo Relison Tintino, Thiago Sampaio de Freitas, Henrique Douglas Melo Coutinho,
Tópico(s)Tea Polyphenols and Effects
ResumoDiseases caused by bacteria are today one of the great problems of present time. Access to over-the-counter medication, the indiscriminate use of antibacterials and high rates of hospitalization have contributed to the increase in cases. This picture has led to the search for new alternative drugs. Thus, secondary metabolites have been reported as a possible treatment option, being evidenced in many researches to ascertain their combination with existing drugs. This research aimed to evaluate the antibacterial effect and the antibiotic activity modifying action of the catechin compound against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus multiresistant strains. The determination of the Minimum Inhibitory Concentration (MIC) and the evaluation of the antimicrobial and potentiating effect were performed by broth microdilution. The MIC obtained forcatechin against all the used strains was indicated as not clinically relevant. The combination of catechin and antibacterial drugs, both Gram-negative and Gram-positive, was synergistic and antagonistic in some drugs. Therefore, phenolic compounds can assist in the fight against infections caused by bacteria.
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