Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria
2017; National Academy of Sciences; Volume: 115; Issue: 2 Linguagem: Inglês
10.1073/pnas.1712051115
ISSN1091-6490
AutoresChanghan Lee, Kamila B. Franke, Shady Mansour Kamal, Hyunhee Kim, Heinrich Lünsdorf, Jasmin Jäger, Manfred Nimtz, Janja Trček, Lothar Jänsch, Bernd Bukau, Axel Mogk, Ute Römling,
Tópico(s)Microbial Metabolic Engineering and Bioproduction
ResumoSignificance Severe heat stress causes massive protein loss by aggregation ultimately causing cell death. Cellular survival relies on protein disaggregation mediated by the Hsp70-ClpB (Hsp100) bichaperone system in most bacteria. Pseudomonas aeruginosa additionally codes for two stand-alone ClpG disaggregases, which had been acquired by horizontal gene transfer by the species and most abundant clone C strains, respectively. These ClpG disaggregases largely contribute to the resolution of protein aggregates to confer superior heat tolerance partially replacing the DnaK-ClpB system.
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