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Prognostic role of tumor-infiltrating CD57-positive lymphocytes in solid tumors: a meta-analysis

2017; Impact Journals LLC; Volume: 9; Issue: 8 Linguagem: Inglês

10.18632/oncotarget.23621

1949-2553

Guoming Hu, Shimin Wang,

Immunotherapy and Immune Responses

// Guoming Hu 1 and Shimin Wang 2 1 Department of General Surgery, Breast and Thyroid Surgery, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, 312000, Zhejiang, China 2 Department of Nephrology, Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, 312000, Zhejiang, China Correspondence to: Guoming Hu, email: hgmplj@126.com Keywords: tumor-infiltrating CD57 + lymphocytes; favorable outcome; solid tumor; meta-analysis Received: October 20, 2017 Accepted: November 27, 2017 Published: December 22, 2017 ABSTRACT The prognostic role of tumor-infiltrating CD57-positive lymphocytes (CD57 + lymphocytes) in human solid tumors remains controversial. Herein, we conducted a meta-analysis including 26 published studies with 7656 patients identified from PubMed and EBSCO to assess the prognostic impact of tumor-infiltrating CD57 + lymphocytes in human solid tumors. We found that CD57 + lymphocyte infiltration significantly improved overall survival (OS) including 1 – year, 3 – year and 5 – year survival, and disease – free survival (DFS) in all types of solid tumors. In stratified analyses, CD57 + lymphocyte infiltration was significantly associated with better OS in hepatocellular, esophageal, head and neck carcinoma, non-small cell lung cancer, 5 – year survival in colorectal cancer, and 3 – year and 5 – year survival in gastric cancer, but not with 1 – year survival in gastric cancer, or 1 – year or 3 – year survival in colorectal cancer. In addition, high density of intratumoral CD57 + lymphocytes was significantly inversely correlated with lymph node metastasis and TNM stage of solid tumor. In conclusion, CD57 + lymphocyte infiltration leads to a favorable clinical outcome in solid tumors, implicating that it is a useful biomarker for prognosis and adoptive immunotherapy based on these cells may be a promising choice for treatment.