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Alterações cardíacas em cães com leishmaniose viscera

2015; Sociedade de Medicina Veterinária do Estado do Rio de Janeiro; Volume: 37; Issue: 4 Linguagem: Inglês

2527-2179

Nicolle Pereira Soares, Alessandra Aparecida Medeiros, Antônio Vicente Mundim, Geórgia Modé Magalhães, Marcus Vinícius Caetano de Sousa, Pedro H. O. Viadanna,

Trypanosoma species research and implications

ABSTRACT. Soares N.P., Medeiros A.A., Mundim A.V., Magalhaes G.M., Souza M.V.C. & Viadanna P.H.O. [Cardiac abnormalities in dogs with visceral leishmaniasis.] Alteracoes cardiacas em caes com leishmaniose visceral. Revista Brasileira de Medicina Veterinaria, 37(4):339-344, 2015. Laboratorio de Patologia Animal, Hospital Veterinario, Faculdade de Medicina Veterinaria, Universidade Federal de Uberlândia, Av. Ceara, s/n, Bloco 2T, Campus Umuarama, Uberlândia, MG 38400-902, Brasil. E-mail: nicolle.pereira@hotmail.com Canine visceral leishmaniasis (CVL) is a chronic disease, endemic and multisystemic, plus a zoonosis. The infected dog may develop various symptoms affecting multiple systems, including the cardiovascular system. For this reason, we used 43 animals positive for leishmaniasis in order to identify the macro and microscopic alterations of the myocardium and relate them to the levels of the enzyme creatine kinase (CK) and Total CK-MB isoenzyme in serum. On macroscopic examination revealed a dilation of the cardiac chambers, thickening of the muscles of the left ventricle with narrowed lumen and thinning of the right ventricular wall with increased chamber. Histologically, the most frequent findings were coagulation necrosis, myofibrillar degeneration and myocarditis. The CK values ranged from 20 to 1236.4 U / L with an average of 263.31 U / L for CK-MB while the average was 937.34 U / L, ranging from 234.94 U / L to 5477, 83U / L, both above the levels established for the canine species. The CK analyzed together with CK-MB isoenzyme are sensitive indicators for muscle injury in humans and domestic animals. Thus, in seropositive dogs, Leishmania causes nonsuppurative linfoplasmocitic myocarditis, myocardial necrosis, accompanied by an increase in the CK and CK-MB.