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Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets

2017; Massachusetts Medical Society; Volume: 377; Issue: 26 Linguagem: Inglês

10.1056/nejmra1703472

1533-4406

Robert Zeiser, Bruce R. Blazar,

Immunodeficiency and Autoimmune Disorders

Chronic GVHD, an autoimmune disease that follows allogeneic hematopoietic-cell transplantation, is characterized by infections and debilitating tissue injury leading to irreversible fibrosis. Insights into the pathophysiology of the disease are providing new therapeutic targets.