Voltar
Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Antiviral Activity of Faramea hyacinthina and Faramea truncata Leaves on Dengue Virus Type‐2 and Their Major Compounds

2017; Wiley; Volume: 15; Issue: 2 Linguagem: Inglês

10.1002/cbdv.201700393

ISSN

1612-1880

Autores

Rodolfo S. Barboza, Lígia M. M. Valente, Thiago Wolff, Iranaia Assunção‐Miranda, Rômulo Leão Silva Neris, Iris Paula Guimarães-Andrade, Mário Gomes,

Tópico(s)

Natural product bioactivities and synthesis

Resumo

The defatted fractions of the Faramea hyacinthina and F. truncata (Rubiaceae) leaf MeOH extracts showed in vitro non-cytotoxic and anti-dengue virus serotype 2 (DENV2) activity in human hepatocarcinoma cell lineage (HepG2). Submitting these fractions to the developed RP-SPE method allowed isolating the antiviral flavanone (2S)-isosakuranetin-7-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (1) from both species and yielded less active sub-fractions. The new diastereoisomeric epimer pair (2S) + (2R) of 5,3',5'-trihydroxyflavanone-7-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (2a/2b) from F. hyacinthina; the known narigenin-7-O-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside (3) from both species; rutin (4) and quercetin-4'-β-d-O-glucopyranosyl-3-O-rutinoside (5) from F. hyacinthina, and kaempferol-3-O-rutinoside (6), erythroxyloside A (7) and asperuloside (8) from F. truncata have been isolated from these sub-fractions. Compounds 4 - 8 are reported for the first time in Faramea spp.

Referência(s)