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Comparative genomics of the major parasitic worms

2018; Nature Portfolio; Volume: 51; Issue: 1 Linguagem: Inglês

10.1038/s41588-018-0262-1

1546-1718

Avril Coghlan, Rahul Tyagi, James A. Cotton, Nancy Holroyd, Bruce A. Rosa, Isheng Jason Tsai, Dominik R. Laetsch, Robin N. Beech, Tim A. Day, Kymberlie Hallsworth-Pepin, Huei‐Mien Ke, Tzu‐Hao Kuo, Tracy J. Lee, John Martin, Rick M. Maizels, Prudence Mutowo, Philip Ozersky, John Parkinson, Adam J. Reid, Neil D. Rawlings, Diogo M. Ribeiro, Lakshmipuram S. Swapna, Eleanor Stanley, David W. Taylor, Nicolas J. Wheeler, Mostafa Zamanian, Xu Zhang, Fiona Allan, Judith E. Allen, Kazuhito Asano, Simon A. Babayan, Germanus S. Bah, Helen Beasley, Hayley M. Bennett, S.A. Bisset, Estela Castillo, Joseph A. Cook, Philip J. Cooper, Teresa Cruz‐Bustos, Carmen Cuéllar, Eileen Devaney, Stephen R. Doyle, Mark L. Eberhard, Aidan M. Emery, Keeseon S. Eom, John S. Gilleard, Daria Gordon, Yvonne Harcus, Bhavana Harsha, John M. Hawdon, Dolores E. Hill, Jane E. Hodgkinson, Petr Horák, Kevin Howe, Thomas Huckvale, Martin Kalbe, Gaganjot Kaur, Taisei Kikuchi, Georgios Koutsovoulos, Sujai Kumar, Andrew R. Leach, Jane Lomax, Benjamin L. Makepeace, Jacqueline B. Matthews, Antonio Muro, N.M. O'Boyle, Peter D. Olson, Antonio Osuna, F Partònò, Kenneth Pfarr, Gabriel Rinaldi, Pilar Foronda, David Rollinson, Mercedes Gómez-Samblás, Hiroshi Sato, Manuela Schnyder, Tomáš Scholz, Myriam Shafie, Vincent N. Tanya, Rafael Toledo, Alan Tracey, Joseph F. Urban, Lian-Chen Wang, Dante S. Zarlenga, Mark Blaxter, Makedonka Mitreva, Matthew Berriman,

Parasites and Host Interactions

Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report a broad comparative study of 81 genomes of parasitic and non-parasitic worms. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritized new potential drug targets and compounds for testing. This comparative genomics resource provides a much-needed boost for the research community to understand and combat parasitic worms. Comparative study of 81 genomes of parasitic and non-parasitic worms identifies gene family births and expanded gene families at key nodes in the phylogeny that are relevant to parasitism and proteins historically targeted for drug development.