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Human Immunodeficiency Virus Type 1 Group O Infection in France: Clinical Features and Immunovirological Response to Antiretrovirals

2017; Oxford University Press; Volume: 66; Issue: 11 Linguagem: Inglês

10.1093/cid/cix1087

1537-6591

Guillemette Unal, Élodie Alessandri-Gradt, Marie Leoz, Juliette Pavie, Clément Lefèvre, Henri Panjo, Charlotte Charpentier, Diane Descamps, Françis Barin, François Simon, Laurence Meyer, Jean‐Christophe Plantier, Jean-Marie Chennebault, P Fialaire, Hélène Le Guillou‐Guillemette, Sami Rehaiem, B. Chanzy, Gaëlle Clavere, J. Gaillat, Laurence Courdavault, Philippe Genet, J. Gerbe, C Benoı̂t, S Honore Bouakline, Anne Waldner, Dominique Bettinger, Catherine Chirouze, N Bernard, Sandrine Reigadas, X Dupont, Jean‐Louis Gaillard, Elyanne Gault, Ene Reimann, G Otterbein, L. Thomas, P. Vaghefi, Michelle Benoit, N Buthiot, Aurélie Goux, V. Chambrin, Claire Deback, Rita Fior, Myriam Moussa, O Antoniotti, Dilek Çoban, Louis Cormerais, Cécile Henquell, Christine Jacomet, O. Lesens, N Chanoine, A Villmant, J L Van Autreve, Marie-Françoise Bloch, Houria Ichou, Vanessa Manceron, E. Mortier, Anqi Zeng, Magali Bouvier–Alias, S Dominguez, A S Lascaux-Cametez, Jean‐Daniel Lelièvre, Yaniv Levy, G Melica-Grégoire, Jean‐Michel Pawlotsky, Pierre Pothier, Anne Waldner, Luca Inchiappa, A Verhaeghe, B Olivier, J P Pathe, Hjg Berthé, Dominique Mathez, V Favret, Didier Troisvallets, E. Vandemeulebroucke, J. Ceccaldi, Z El Harif, Laurence Bocket, P Barbut, F. Chaix, Céline Lambert, T Lambolez, J Miatezila, Olivia Son, Pascal Brunet, Céline Chappé, C Dhiver, V. Lecomte, Line Meddeb, Isabelle Poizot‐Martin, Catherine Tamalet, J Valadier, Geneviève Beck-Wirth, M Benomar, Jean-Marie Delarbre, J M Peter, S Bevilacqua, Véronique Venard, V. Daneluzzi, N Idri, Bogar O. Araujo-Montoya, Valentine Marie Ferré, Éric Garnier, H. Hue, L Larmet, P Point, François Raffi, V Reliqiet, Audrey Rodallec, S. Secher, P Amoyel, Estelle Botton, Mirosław Janowski, Y Le Cocguic, P Deleplanque, Jean-Michel Descamps, M Lapine, Shyam Sunder, M. Chansombat, C. Charpentier, Florence Damond, Boubacar Diallo, Xavier Duval, Zélie Julia, Roland Landman, Sylvie LeGac, C. Rioux, P Yéni, Anne Krivine, Paul Blanche, Agnès Cros, Philippe Gazalet, Jade Ghosn, Anne Krivine, A Sobel, Béatrice Berçot, Myriam Diemer, Marica Parrinello, C Bey Boumezrag, Loïc Bodard, Sandra Gibert, F X Huche, L Raffenne, M Strebler, Caroline Blanc, E Bourzam, Boris Hansel, Catherine Lupin, Marc Wirden, E Bourzam, Lio Collias, J Effa, Chan‐Hee Jung, J. Pavie, Hélène Péré, Ali Si Mohamed, Constance Delaugerre, Laurence Gérard, Bénédicte Loze, Sarah Maylin, R Nabias, Diane Ponscarme, Jean‐François Deleuze, Felix D. Rozenberg, Bassam Bachour, Firouzé Bani‐Sadr, Julie Chas, M. Hamidi, L Kherallah, S. Le Nagat, Catherine Le Pendeven, F. Moreau, Jean‐Claude Nicolas, Véronique Schneider, M.-D. Tabone, G. Vaudre, G. Giraudeau, G. Le Moal, D Plainchamp, G Blondin, I Dorval, J C Duthé, Pascale Perfezou, J L Berger, Véronique Brodard, I Kmiec, C. Rouger, C. Strady, J M Chappelin, Anne Maillard, Mariusz Z. Ratajczak, Y Debab, Fabiana de Oliveira, Agnès Depatureaux, I. Gueït, Véronique Lemee, David Théron, I Pasdeloup, Pelayo Camps, C. Bigaillon, C. Ficko, Christine Imbert, C. Rapp, C Grand, Christophe Michau, Dominique Bornarel, P. Devillier, Éric Farfour, C. Majerholc, D Vignon, D Zucman, M El Addouli, Marie Danjoux, J Journe, Y. Leveneur, B. Marchou, Florence Nicot, Françoise Clary, Stefan Bonné,

HIV/AIDS Research and Interventions

To obtain reliable clinical data of human immunodeficiency virus type 1 group O (HIV-1/O) infection, and immunovirological responses to combination antiretroviral therapy (cART), in a large series of 101 patients.Piecewise linear models were used to estimate CD4 count before and after cART initiation. Kaplan-Meier survival curves were used to estimate time to reach clinical stage C before antiretroviral therapy (ART) and to analyze time to achieve a plasma viral load (pVL) <40 copies/mL following cART initiation. Immunovirological response was assessed at the most recent visit in patients on active follow-up.Data showed a 16.6% cumulative probability of reaching stage C within 5 years following diagnosis, and a mean CD4 decrease of -30.5 cells/μL/year. cART initiation in ART-naive patients led to a mean CD4 gain of 147 cells/μL after 12 months, and to a median pVL of <40 copies/mL after 3.8 months for 89.3%. Initiation with a nonrecommended nonnucleoside reverse transcriptase inhibitor-based vs a ritonavir-boosted protease inhibitor-based regimen resulted in a much smaller gain of around 100 CD4 cells/μL after 1 year. Patients on follow-up since 2007 had a median CD4 count of 498 cells/μL, and 87% had a pVL <40 copies/mL at the most recent follow-up visit.This work provides unique data on HIV-1/O infection, in favor of a milder natural evolution than HIV-1 group M (HIV-1/M) and of a highly efficient current management, based on HIV-1/M guidelines, despite genetic divergence. Studies of comparable HIV-1/M and HIV-1/O populations are needed to confirm these results.