Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
2017; Royal Society of Chemistry; Volume: 54; Issue: 6 Linguagem: Inglês
10.1039/c7cc08286j
ISSN1364-548X
AutoresDavid Bouzada, Iria Salvadó, Ghofrane Barka, Gustavo Rama, José Martínez‐Costas, Romina Lorca, Álvaro Somoza, Manuel Melle‐Franco, M. Eugenio Vázquez, Miguel Vázquez López,
Tópico(s)Metal complexes synthesis and properties
ResumoA set of Ru(ii) metallopeptides containing the dppz ligand has been synthesized using SPPS methods. Fluorescence titration studies show that those metallopeptides featuring an octaarginine tail display a large binding preference for DNA G-quadruplex structures over those lacking it, and also that the interplay between the octoarginine functionalization and the ancillary ligand in the complex has an essential role in the recognition process. Furthermore, the oligoarginine metallopeptides are also efficiently internalized, causing cell death with signs of apoptosis.
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