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BIBTEX RIS

Radical Scavenger Capacity of Jabuticaba Fruit ( Myrciaria cauliflora ) and Its Biological Effects in Hypertensive Rats

2017; Hindawi Publishing Corporation; Volume: 2017; Issue: 1 Linguagem: Inglês

10.1155/2017/2383157

1942-0900

Camila Gabriela de Souza, Daniela Medeiros Lobo de Andrade, Juliana Bahia Reis Jordão, Renato Ivan de Ávila, Leonardo Luiz Borges, Boniek G. Vaz, Marize Campos Valadares, Eric de Souza Gil, Edemilson Cardoso da Conceição, Matheus Lavorenti Rocha,

Botanical Research and Applications

Jabuticaba is an exotic fruit native to Brazil that has been arousing medicinal interest. Using chemical (HPLC-PDA, resonance mass spectra, and NMR), electroanalytical (differential pulse voltammetry, radical scavenging assay), and pharmacological ( in vivo and in vitro ) approaches, we have identified its bioactive compounds and hypotensive effects on hypertensive rats. The hydroalcoholic extract of jabuticaba (HEJ) presents a great quantity of phenolic compounds, and several molecules with hydroxyl groups present high efficiency as an antioxidant. The treatment with HEJ (100 and 300 mg/kg/day, for four weeks) presented hypotensive effects on L-NAME-induced hypertensive rats, possibly improving the nitric oxide bioavailability because of its high antioxidant potential. Furthermore, renal and cardiac hypertrophies were also attenuated after the HEJ treatment. Moreover, the vascular responses to contractile and dilating agonists were improved with the HEJ treatment, which is also able to induce nitric oxide production in endothelial cells.