N6 - tert -Butoxycarbonyl derivatives of sydnone imines: Preparation and synthetic use
2018; Elsevier BV; Volume: 59; Issue: 8 Linguagem: Inglês
10.1016/j.tetlet.2018.01.019
ISSN1873-3581
AutoresI. A. Cherepanov, Alina S. Samarskaya, Ivan A. Godovikov, Konstantin А. Lyssenko, Anastasia A. Pankratova, V. N. Kalinin,
Tópico(s)Phenothiazines and Benzothiazines Synthesis and Activities
ResumoA highly efficient gram-scale method for the C(4)-functionalization of sydnone imine hydrochloride derivatives was developed. This new approach was realized through consecutive reactions including the preparation of a C(3)-substituted N6-tert-butoxycarbonyl sydnone imine derivative, deprotonation with n-BuLi and reaction of the lithiated-intermediate with an electrophilic agent, and removal of the Boc protecting group.
Referência(s)