Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
2018; Massachusetts Medical Society; Volume: 378; Issue: 3 Linguagem: Inglês
10.1056/nejmoa1709449
ISSN1533-4406
AutoresSergey I. Nikolaev, Sandra Vetiska, Ximena Bonilla, Émilie Boudreau, Suvi Jauhiainen, Behnam Rezai Jahromi, Nadiya Khyzha, Peter V. DiStefano, Santeri Suutarinen, Tim‐Rasmus Kiehl, Vítor Mendes Pereira, Alexander M. Herman, Timo Krings, Hugo Andrade-Barazarte, Takyee Tung, Taufik A. Valiante, Gelareh Zadeh, Michael Tymianski, Tuomas Rauramaa, Seppo Ylä‐Herttuala, Joshua D. Wythe, Stylianos E. Antonarakis, Juhana Frösén, Jason E. Fish, Ivan Radovanovic,
Tópico(s)Cerebrovascular and genetic disorders
ResumoSporadic arteriovenous malformations of the brain, which are morphologically abnormal connections between arteries and veins in the brain vasculature, are a leading cause of hemorrhagic stroke in young adults and children. The genetic cause of this rare focal disorder is unknown.
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