S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense
2018; American Association for the Advancement of Science; Volume: 359; Issue: 6371 Linguagem: Inglês
10.1126/science.aam5809
ISSN1095-9203
AutoresYuefeng Huang, Kairui Mao, Xi Chen, Ming-an Sun, Takeshi Kawabe, Weizhe Li, Nicholas Usher, Jinfang Zhu, Joseph F. Urban, William E. Paul, Ronald N. Germain,
Tópico(s)Eosinophilic Esophagitis
ResumoInflammatory ILC2s are itinerant sentinels Group 2 innate lymphoid cells (ILC2s) are a population of immune cells that play important roles in tissue homeostasis and barrier immunity to helminths. Recent work has suggested that ILC2s are primarily long-term residents of tissues that do not readily recirculate. Huang et al. now demonstrate, however, that these findings do not necessarily hold true for the interleukin-25 (IL-25)–responsive KLRG1 hi “inflammatory” ILC2 (iILC2) subset (see the Perspective by Mjösberg and Rao). In response to exogenous IL-25 or helminth infection, iILC2 precursors in the small intestinal lamina propria proliferate and alter their expression of sphingosine 1-phosphate (S1P) receptors. They then traffic to both lymphatic and nonlymphatic organs in a partly S1P-dependent manner, participating in vital anti-helminth and tissue repair responses. Science , this issue p. 114 ; see also p. 36
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