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Abatacept in patients with rheumatoid arthritis and interstitial lung disease: A national multicenter study of 63 patients

2018; Elsevier BV; Volume: 48; Issue: 1 Linguagem: Inglês

10.1016/j.semarthrit.2017.12.012

1532-866X

C. Fernández-Díaz, J. Loricera, Santos Castañeda, Raquel López‐Mejías, C. Ojeda-Garcia, Alejandro Olivé, Samantha Rodríguez‐Muguruza, Patrícia Carreira, Trinidad Pérez-Sandoval, Miriam Retuerto, Evelin C. Cervantes-Pérez, Bryan J. Flores-Robles, Blanca Hernández‐Cruz, Ana Urruticoechea, O. Maíz, Luis Arboleya, Gema Bonilla, Íñigo Hernández-Rodríguez, Desirée Palma, Concepción Delgado, R. Expósito-Molinero, Ana Ruibal-Escribano, Belén Álvarez-Rodríguez, J. M. Blanco-Madrigal, José Antonio Bernal, Paloma Vela, Manuel Romero‐Gómez, C. Fito, F. Ortíz-Sanjuán, Javier Narváez, M. Moreno, Mireia López-Corbeto, Natalia Mena‐Vázquez, Clara Aguilera-Cros, Susana Romero-Yuste, Sergi Ordóñez, Ignacio Villa-Blanco, M. Carmen Gonzélez-Vela, Víctor Manuel Mora Cuesta, Natalia Palmou‐Fontana, José L. Hernández, Miguel Á. González‐Gay, Ricardo Blanco,

Rheumatoid Arthritis Research and Therapies

Interstitial lung disease (ILD) is one of the most serious complications of rheumatoid arthritis (RA). In the present study, we aimed to assess the efficacy of abatacept (ABA) in patients with ILD associated to RA. National multicenter, non-controlled, open-label registry study of RA patients with ILD treated with ABA. 63 patients (36 women) with RA-associated ILD undergoing ABA therapy were studied. The mean ± standard deviation age at the time of the study was 63.2 ± 9.8 years. The median duration of RA and ILD from diagnosis were 6.8 and 1 year, respectively. RA was seropositive in 55 patients (87.3%). In 15 (23.8%) of 63 patients the development of ILD was closely related to the administration of synthetic or biologic disease modifying anti-rheumatic drugs. After a follow-up of 9.4 ± 3.2 months, two-thirds of patients remained stable whereas one-quarter experienced improvement in the Modified Medical Research Council scale. At that time forced vital capacity remained stable in almost two-thirds of patents and improved in one out of five patients assessed. Also, diffusing capacity of the lung for carbon monoxide remained stable in almost two-thirds and showed improvement in a quarter of the patients assessed. At 12 months, 50% of the 22 patients in whom chest HRCT scan was performed due persistence of respiratory symptoms showed stabilization, 8 (36.4%) improvement and 3 worsening of the HRCT scan pattern. Eleven of 63 patients had to discontinue ABA, mainly due to adverse events. ABA appears to be an effective in RA-associated ILD.