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Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018; National Academy of Sciences; Volume: 115; Issue: 3 Linguagem: Inglês

10.1073/pnas.1714421115

1091-6490

Meng Qiu, Dou Wang, Weiyuan Liang, Liping Liu, Yin Zhang, Xing Chen, David K. Sang, Chenyang Xing, Zhongjun Li, Biqin Dong, Feng Xing, Dianyuan Fan, Shiyun Bao, Han Zhang, Yihai Cao,

Extracellular vesicles in disease

Significance Precision delivery of cancer drugs to tumor site is crucial for improving therapeutic efficacy and minimizing adverse effects. Despite tremendous efforts, current drug delivery systems remain an unmet clinical need for cancer therapy. Herein, we propose a unique concept of applying external light to control drug delivery in cancer tissues. In preclinical cancer models, we demonstrate that the near-infrared light-induced decomposition of black phosphorus hydrogel accurately releases drugs in tumor tissues to eradicate subcutaneous breast and melanoma cancers without causing any adverse effects. We believe that our therapeutic system can be used for effective treatment of most cancer types. Our findings may likely bring about a paradigm shift in clinical treatment of cancer and millions of cancer patients will benefit from our findings.