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SLE-Associated Defects Promote Altered T Cell Function

2017; Begell House; Volume: 37; Issue: 1 Linguagem: Inglês

10.1615/critrevimmunol.2018025213

2162-6472

José C. Crispín, Christian M. Hedrich, Abel Suárez‐Fueyo, Denis Comte, George C. Tsokos,

Immune Cell Function and Interaction

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease linked to profound defects in the function and phenotype of T lymphocytes. Here, we describe abnormal signaling pathways that have been documented in T cells from patients with SLE and discuss how they impact gene expression and immune function, in order to understand how they contribute to disease development and progression.