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Human Immunodeficiency Virus-1 Drug Resistance Patterns Among Adult Patients Failing Second-Line Protease Inhibitor-Containing Regimens in Namibia, 2010–2015

2018; Oxford University Press; Volume: 5; Issue: 2 Linguagem: Inglês

10.1093/ofid/ofy014

2328-8957

Souleymane Sawadogo, Andreas Shiningavamwe, Clay Roscoe, Andrew L. Baughman, Taffa Negussie, Gram Mutandi, Chunfu Yang, Ndapewa Hamunime, Simon Agolory,

Pneumocystis jirovecii pneumonia detection and treatment

Three hundred sixty-six adult patients in Namibia with second-line virologic failures were evaluated for human immunodeficiency virus drug-resistant (HIVDR) mutations. Less than half (41.5%) harbored ≥1 HIVDR mutations to standardized second-line antiretroviral therapy (ART) regimen. Optimizing adherence, viral load monitoring, and genotyping are critical to prevent emergence of resistance, as well as unnecessary switching to costly third-line ART regimens.