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Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

2018; American Association for the Advancement of Science; Volume: 10; Issue: 423 Linguagem: Inglês

10.1126/scitranslmed.aai7795

1946-6242

Ken Hui, Heriberto Fernandez-Hernandez, Jianzhong Hu, Adam Schaffner, Nathan Pankratz, Nai-Yun Hsu, Ling-Shiang Chuang, Shai Carmi, Nicole Villaverde, Xianting Li, Manual Rivas, Adam P. Levine, Xiuliang Bao, Philippe Ronel Labrias, Talin Haritunians, Darren Ruane, Kyle Gettler, Ernie Chen, Dalin Li, Elena Schiff, Nikolas Pontikos, Nir Barzilai, Steven R. Brant, Susan Bressman, Adam S. Cheifetz, Lorraine N. Clark, Mark J. Daly, Robert J. Desnick, Richard H. Duerr, Seymour Katz, Todd Lencz, Richard H. Myers, Harry Ostrer, Laurie J. Ozelius, Haydeh Payami, Yakov Peter, John D. Rioux, Anthony W. Segal, William K. Scott, Mark S. Silverberg, Jeffery M. Vance, Iban Ubarretxena‐Belandia, Tatiana Foroud, Gil Atzmon, Itsik Pe’er, Yiannis A. Ioannou, Dermot McGovern, Zhenyu Yue, Eric E. Schadt, Judy H. Cho, Inga Peter,

Whipple's Disease and Interleukins

Crohn’s disease (CD)–associated variants in the LRRK2 gene for risk (N2081D) and for protection (N551K) mediate shared effects in CD and Parkinson’s disease.