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Immunotherapy Bridge 2017 and Melanoma Bridge 2017: meeting abstracts

2018; BioMed Central; Volume: 16; Issue: S1 Linguagem: Inglês

10.1186/s12967-017-1352-z

1479-5876

David Carbone, Michael F. Sharpnack, Kai He, Lisa H. Butterfield, Alexander Eggermont, María González‐Cao, Niki Karachaliou, Guillermo Crespo, Erika Aldeguer, Ana Drozdowskyj, Ana Giménez‐Capitán, Cristina Teixidó, Miguel Ángel Molina‐Vila, Santiago Viteri, Salvador Martín‐Algarra, Elisabeth Pérez‐Ruiz, Iván Márquez‐Rodas, Delvys Rodríguez‐Abreu, Remei Blanco, Teresa Puértolas, Maria Angeles Royo, Rafael Rosell, Maria Libera Ascierto, Svetlana Hamm, Tanja Wulff, Kerstin Kronthaler, Sabine Schrepfer, Ulrike Parnitzke, Anne Catherine Bretz, Roland Baumgartner, Veronica Ferrucci, Francesco Paolo Pennino, Luisa Dassi, Fatemeh Asadzadeh, Roberto Siciliano, Marianeve Carotenuto, Daniela Spano, Cristina M. Chiarolla, Adelaide Greco, Monica Cantile, Maurizio Di Bonito, Gerardo Botti, Jonathan Vandenbussche, Kris Gevaert, Massimo Zollo, Teresa Amaral, Ioanna Tampouri, Ulrike Keim, Thomas Eigentler, Claus Garbe, Andrea Forschner, Alessandra Cesano, Sarah Warren, Duane Moogk, Kaitao Li, Zhou Yuan, Zhong Shi, Zhiya Yu, Ivan Liadi, William Rittase, Victoria Fang, Janna Dougherty, Arianne Pérez-García, Iman Osman, Navin Varadarajan, Nicholas P. Restifo, Alan B. Frey, Cheng Zhu, Michelle Krogsgaard, Claire Vanpouille‐Box, Silvia C. Formenti, Sandra Demaria, Cristiana Lo Nigro, Alexander Renziehausen, Andreas G. Tzakos, Hexiao Wang, Bhavya Rao, Rubeta Matin, Catherine Α. Harwood, Daniela Vivenza, Federica Tonissi, Marcella Occelli, Lynda Weir, Li Su, Van Ren Sim, Kevin O’Neill, Alan Evans, Alastair M. Thompson, Peter W. Szlosarek, Colin Fleming, Charlotte M. Proby, Nelofer Syed, Marco Merlano, Tim Crook, Robert Ferguson, Danny Simpson, Carlos Martínez, Matjaž Vogelsang, Esther Kazlow, Melissa Wilson, Anna C. Pavlick, Jeffrey S. Weber, Ryan J. Sullivan, Keith T. Flaherty, Antoni Ribas, Tomas Kirchhoff, Antonio D’Avino, Licia Guida, Augusto Cosacco, Roberta D’Aniello, Piera Maiolino, Teresa Tramontano, Maria R. Sarno, Ida Palazzo, Angela Di Napoli, Gianclaudio Acunzo, Mariarosanna De Fina, Antonia Silvestri, Monica Specchia, Michela Musacchio, Gianfranco Giglio, Francesco Carrozza, Liberato Di Lullo, Gian Marco De Maddi, Adele Venturelli, Elisabetta Gambale, Alessia Gatta, Davide Brocco, Consiglia Carella, Michele De Tursi, Thomas F. Gajewski, Costanza Maria Cristiani, Rossana Tallerico, Valeria Ventura, Mariaelena Capone, Gabriele Madonna, Domenico Mallardo, Eliška Selinger, Cinzia Garofalo, Elina Staaf, Ester Simeone, Antonio M. Grimaldi, Genny Del Zotto, Elio Gulletta, Gennaro Ciliberto, Alessandro Moretta, Paolo A. Ascierto, Ennio Carbone, Susan Costantini, Angela Sorice, Francesca Capone, Gennaro Ciliberto, Alfredo Budillon, Carolina Cauchi, G Sciancalepore, Cristiana Lo Nigro, Michela Rovera, Chiara Varamo, Zelda Seia, S. Palazzini, Fabiana Errico, Davide Basso, Laura Quaranta, Giuseppe Forte, Fulvio Lavagna, Silvia Violante, Paolo Bosio, Laura Lattanzio, Marco Merlano, Mike Gowen, Jeremy Tchack, Hua Zhou, Keith M. Giles, Scott Paschke, Una Moran, David Fenyö, A. Tsirigos, Michael E. Pacold, Silvana Morello, Claudia Sorrentino, Diana Giannarelli, Aldo Pinto, Federica Fratangelo, Rosaria Falcone, Vito Vanella, Dirk Schadendorf, Karl D. Lewis, Michele Maio, Lev V. Demidov, Mario Mandalà, Igor Bondarenko, Christopher Herbert, Andrzej Maćkiewicz, Piotr Rutkowski, Alexander Guminski, Grant R. Goodman, Brian Simmons, Chenglin Ye, Gregory Hooper, Matthew Wongchenko, Yibing Yan, Frank Hermann, Astrid Ammendola, Svetlana Hamm, René Bartz, Bulotta Alessandra, Colombo Letizia, Mirabile Aurora, Lazzari Chiara, M Raffaele, Danilo Parolini, Rizzo Nathalie, Martella Stefano, Modorati Giulio, B E Callejas Pina, Cestone Enza, Bellinzona Federica, Miserocchi Elisabetta, Luca Gianni, Gregorc Vanesa, Sanjiv S. Agarwala, B. Mark Smithers, Axel Haushild, Eric Watcher, Luigi Fattore, Ciro Francesco Ruggiero, Domenico Liguoro, Andrea Cerri, Maria Elena Pisanu, Rita Mancini,

CAR-T cell therapy research

Immunotherapy approaches targeting the PD-1 pathway have shown some clinical benefits in a fraction of patients with lung cancer, but expression of PD-L1 has proven to be an imperfect biomarker of efficacy.Recent studies have shown that tumor mutation burden (TMB) is also correlated with outcome and that it appears to be independent of PD-L1.TMB, however, only indirectly measures the number of neoantigenic peptides presented on tumor cell surface class I MHC and predicted MHC matches may be an even better predictor of benefit.In addition, mutations in genes such as LKB1 may modulate the immune response, and mutations in the antigen presentation pathway may block it altogether.Mutations in DNA repair pathway genes may increase the number of potential neoantigens.Thus in depth analysis of tumor somatic genomics could lead to better patient selection for immunotherapy. SITC session-evolving topics in cancer immunotherapy K2 Discussion about evolving topics in cancer immunotherapy