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The hitchhiker’s guide to the chemical-biological galaxy

2018; Elsevier BV; Volume: 23; Issue: 3 Linguagem: Inglês

10.1016/j.drudis.2018.01.007

1878-5832

Giulia Opassi, Alessandro Gesù, Alberto Massarotti,

Bioinformatics and Genomic Networks

We are used to considering chemical and biological spaces as two different entities; although they represent a more-interconnected world, in fact they represent a Yin-Yang concept in drug discovery. Chemical-biological space is as vast as the universe and, as Douglas Adams famously said, 'Space is big. You just won't believe how vastly, hugely, mind-bogglingly big it is'. However, many researchers are convinced that it is not so infinite, and are designing computational and experimental tools to help identify and explore all possible chemical-biological space. Here, we provide an analysis of their approaches and discuss possible future research studies.