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Alveolar bone repair with strontium- containing nanostructured carbonated hydroxyapatite

2018; UNIVERSIDADE DE SÃO PAULO; Volume: 26; Linguagem: Inglês

10.1590/1678-7757-2017-0084

1678-7765

André Boziki Xavier do Carmo, Suelen Cristina Sartoretto, Adriana Terezinha Neves Novellino Alves, José Mauro Granjeiro, Fúlvio Borges Miguel, José de Albuquerque Calasans‐Maia, Mônica Diuana Calasans‐Maia,

Dental materials and restorations

This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials. Twenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 μm bone blocks were obtained for histomorphometric evaluation. The parameters evaluated were remaining biomaterial, loose connective tissue and newly formed bone in a standard area. Statistical analysis was performed by Mann-Withney and and Wilcoxon tests at 95% level of significance. The histomorphometric results showed that the microspheres showed similar fragmentation and bio-absorbation (p>0.05). We observed the formation of new bones in both groups during the same experimental periods; however, the new bone formation differed significantly between the weeks 1 and 6 (p=0.0039) in both groups. The CHA and SrCHA biomaterials were biocompatible, osteoconductive and bioabsorbable, indicating their great potential for clinical use as bone substitutes.