Portal de Periódicos da CAPES

Pneumonia as a cardiovascular disease

2018; Wiley; Volume: 23; Issue: 3 Linguagem: Inglês

10.1111/resp.13233

1440-1843

Marcos I. Restrepo, Luis Felipe Reyes,

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

ABSTRACT Community‐acquired pneumonia (CAP) is an important cause of death around the globe. Up to 30% of patients admitted to hospital for CAP develop cardiovascular complications (i.e. new/worsening heart failure, new/worsening arrhythmias, myocardial infarctions and/or strokes), acutely and up to 10 years thereafter. Cardiac complications result from complex interactions between preexisting conditions, relative ischaemia, upregulation of the sympathetic system, systemic inflammation and direct pathogen‐mediated damage to the cardiovascular system. The exact mechanisms underlying the direct host–pathogen interactions are of great interest to identify potential therapeutic and preventative targets for CAP. In this review, we summarize the epidemiological data, risk factors and the pathogen‐driven cardiovascular damage affecting patients with CAP.