Produção Nacional
Revisado por pares
Targeted knockout of a chemokine-like gene increases anxiety and fear responses
2018; National Academy of Sciences; Volume: 115; Issue: 5 Linguagem: Inglês
10.1073/pnas.1707663115
ISSN1091-6490
AutoresJung-Hwa Choi, Yun-Mi Jeong, Sujin Kim, Boyoung Lee, Krishan Ariyasiri, Hyun-Taek Kim, Seung‐Hyun Jung, Kyu-Seok Hwang, Tae‐Ik Choi, Chulo Park, Won‐Ki Huh, Michael Carl, Jill A. Rosenfeld, Salmo Raskin, Alan Ma, Jozef Gécz, Hyung‐Goo Kim, Jin‐Soo Kim, Ho‐Chul Shin, Doo-Sang Park, Robert Gerlai, Bradley B. Jamieson, Joon S. Kim, Karl J. Iremonger, Sang H. Lee, Hee‐Sup Shin, Cheol‐Hee Kim,
Tópico(s)Aquaculture disease management and microbiota
ResumoSignificance Emotion-related responses, such as fear and anxiety, are important behavioral phenomena in most animal species, as well as in humans. However, the underlying mechanisms of fear and anxiety in animals and in humans are still largely unknown, and anxiety disorders continue to represent a large unmet medical need in the human clinic. Animal models may speed up discovery of these mechanisms and may also lead to betterment of human health. Herein, we report the identification of a chemokine-like gene family, samdori ( sam ), and present functional characterization of sam2 . We observed increased anxiety-related responses in both zebrafish and mouse knockout models. Taken together, these results support a crucial and evolutionarily conserved role of sam2 in regulating anxiety-like behavior.
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