Portal de Periódicos da CAPES

Immune Cytokines and Their Receptors in Inflammatory Pain

2018; Elsevier BV; Volume: 39; Issue: 3 Linguagem: Inglês

10.1016/j.it.2017.12.003

1471-4981

Andrew D. Cook, Anne Deen Christensen, Damini Tewari, Stephen B. McMahon, John A. Hamilton,

Stress Responses and Cortisol

There is burgeoning interest in the interaction between the immune and nervous systems. Pain is mediated by primary sensory neurons (nociceptors) that can respond to a variety of thermal, mechanical and chemical signals. Cytokines are now recognized as important mediators of inflammatory pain. They can induce nociceptor sensitization indirectly via mediators, wherein neurons become primed and thus become more responsive to stimulation; alternatively, there is also evidence that cytokines can directly activate neurons via their specific receptors present on the neuronal cells. We review here the evidence for and against these respective mechanisms, focusing on arthritis and inflammatory skin models. A number of striking inconsistencies amongst the conclusions made in the literature are highlighted and discussed.