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Serological Markers of Recent Campylobacter jejuni Infection in Patients with Guillain–Barré Syndrome in the State of Piauí, Brazil, 2014–2016

2018; American Society of Tropical Medicine and Hygiene; Volume: 98; Issue: 2 Linguagem: Inglês

10.4269/ajtmh.17-0666

1476-1645

Cintya de Oliveira Souza, Marcelo A. C. S. Vieira, Francisca M. A. Batista, Kelsen Dantas Eulálio, Jéssica Milena Moura Neves, Laís Carvalho de Sá, Leni Célia Reis Monteiro, Walfrido S. Almeida-Neto, Raimunda do Socorro da Silva Azevedo, Dorcas Lamounier Costa, Ana Cecília Ribeiro Cruz,

Viral Infections and Immunology Research

In countries where poliomyelitis has been eradicated, Guillain-Barré syndrome (GBS) is the leading cause of acute flaccid paralysis. The range of infections that precede GBS in Brazil is unknown. Campylobacter jejuni infection is the most frequent trigger of GBS worldwide. Given the lack of systematic surveillance of diarrheal diseases, particularly in adults, the incidence of enteritis caused by C. jejuni in developing countries is unknown. From 2014 to 2016, pretreatment serum samples from 63 GBS patients were tested by immunoglobulin M (IgM) enzyme-linked immunosorbent assay for C. jejuni. Campylobacter jejuni IgM antibodies were detected in 17% (11/63) of the samples. There was no association between serological positivity (IgM) for C. jejuni and the occurrence of diarrhea among the investigated cases (P = 0.36). Hygiene measures, basic sanitation, and precautions during handling and preparation of food of animal origin may help prevent acute flaccid paralysis.