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Interaction between physical activity, PITX1 rs647161 genetic polymorphism and colorectal cancer risk in a Korean population: a case-control study

2018; Impact Journals LLC; Volume: 9; Issue: 7 Linguagem: Inglês

10.18632/oncotarget.24136

1949-2553

Madhawa Gunathilake, Jeonghee Lee, Young Ae Cho, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim,

Nutrition, Genetics, and Disease

// Madhawa Neranjan Gunathilake 1 , Jeonghee Lee 2 , Young Ae Cho 2 , Jae Hwan Oh 3 , Hee Jin Chang 3 , Dae Kyung Sohn 3 , Aesun Shin 4 and Jeongseon Kim 2 1 Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do 10408, South Korea 2 Department of Biomedical Science, Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do 10408, South Korea 3 Center for Colorectal Cancer, National Cancer Center Hospital, National Cancer Center, Goyang-si, Gyeonggi-do 10408, South Korea 4 Department of Preventive Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul 03080, South Korea Correspondence to: Jeongseon Kim, email: jskim@ncc.re.kr Aesun Shin, email: shinaesun@snu.ac.kr Keywords: physical activity; PITX1; genetic polymorphism; colorectal cancer; interaction Received: June 21, 2017 Accepted: December 26, 2017 Published: January 10, 2018 ABSTRACT This study assessed the interaction between physical activity and colorectal cancer (CRC) risk based on a polymorphism in the paired-like homeodomain 1 ( PITX1 ) gene in Koreans. In total, 923 cases and 1,846 controls were enrolled at the National Cancer Center, Korea. Subjects who did regular exercise showed a significantly reduced risk of CRC than those did not exercise regularly (OR = 0.37, 95% CI = 0.30–0.45). Subjects in the highest tertile of metabolic equivalents of task (MET)-minutes per week showed a significantly lower risk of CRC (OR = 0.62, 95% CI = 0.48–0.79, p-trend < 0.001). In the dominant model, minor allele carriers showed a significantly higher risk of CRC than subjects homozygous for the major allele (OR = 1.46, 95% CI = 1.18–1.80). The PITX1 genetic variant showed significant interactions with regular exercise and CRC risk (p-interaction = 0.018) and colon cancer risk (p-interaction = 0.029) among all subjects. Subjects who carried at least one minor allele and did not regularly exercise showed a greater risk of CRC (OR = 1.81, 95% CI = 1.37–2.41). Subjects who were homozygous for the major allele with high physical activity showed a significantly reduced risk of CRC (OR = 0.56, 95% CI = 0.38–0.82). Thus, individuals with PITX1 genetic variants can have benefit from physical activity regarding prevention of CRC risk in a Korean population.