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Effect of thymectomy on refractory autoimmune status epilepticus

2018; Elsevier BV; Volume: 317; Linguagem: Inglês

10.1016/j.jneuroim.2018.01.009

1872-8421

Alberto Vogrig, Giada Pauletto, Enrico Belgrado, Enrico Pegolo, Carla Di Loreto, Véronique Rogemond, Jérôme Honnorat, Roberto Eleopra,

Glycogen Storage Diseases and Myoclonus

Refractory status epilepticus (RSE) is an increasingly recognized manifestation of autoimmune encephalitis, which can occur either as a paraneoplastic or non-paraneoplastic disorder. The effect of tumor removal in paraneoplastic status epilepticus has never been explored systematically, although early tumor treatment is usually recommended. In this study, we report clinical, pathological and EEG findings of a patient who developed RSE as one of multiple paraneoplastic manifestations of thymoma and the effect of thymectomy on seizure outcome. To our knowledge, this is the first report of successful treatment of RSE with tumor removal in paraneoplastic encephalitis.