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Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis

2018; BMJ; Volume: 77; Issue: 4 Linguagem: Inglês

10.1136/annrheumdis-2017-212372

1468-2060

Lourdes Ortiz‐Fernández, F. David Carmona, Raquel López-Mejías, María Francisca González‐Escribano, Paul Lyons, Ann W. Morgan, Amr H. Sawalha, Peter A. Merkel, Kenneth G. C. Smith, Miguel Á. González‐Gay, Javier Martı́n,

Mast cells and histamine

Systemic vasculitides represent a heterogeneous group of rare complex diseases of the blood vessels with a poorly understood aetiology. To investigate the shared genetic component underlying their predisposition, we performed the first cross-phenotype meta-analysis of genetic data from different clinically distinct patterns of vasculitis.