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Autophagy in Neurodegeneration: Can’t Digest It, Spit It Out!

2018; Elsevier BV; Volume: 28; Issue: 3 Linguagem: Inglês

10.1016/j.tcb.2018.01.001

1879-3088

Valentin J.A. Barthet, Kevin M. Ryan,

Endoplasmic Reticulum Stress and Disease

The autophagy-lysosome pathway maintains cellular homeostasis and protects against neurodegenerative disorders. Recent findings show that autophagy can be impaired in these diseases, and that the cell activates an alternative Golgi-mediated degradation pathway, leading to expulsion of toxic protein aggregates. Ultimately this process leads to nuclear breakdown and neuronal cell death.