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Quimioterapia convencional e metronômica no tratamento de cadela com carcinoma em tumor misto em estadio avançado - Relato de caso

2016; Sociedade de Medicina Veterinária do Estado do Rio de Janeiro; Volume: 38; Linguagem: Inglês

2527-2179

Keidylânia da Costa Santos, Luciano Guimarães Tanajura Requião, Lorena Gabriela Rocha Ribeiro, Mário Jorge Melhor Heine D’Assis, Carlos Humberto da Costa Vieira Filho, Karine Araújo Damasceno, Eduardo Luiz Trindade Moreira, Alessandra Estrela Lima,

Cancer Research and Treatments

ABSTRACT. Santos K.C., Requiao L.G.T., Ribeiro L.G.R., D’Assis M.J.M.H., Vieira-Filho C.H.C., Damasceno K.A., Moreira E.L.T. & Estrela-Lima A. [Treatment with conventional and metronomic chemotherapy in advanced stage of canine carcinoma in mixed tumor - Case report.] Quimioterapia convencional e metronomica no tratamento de cadela com carcinoma em tumor misto em estadio avancado - Relato de caso. Revista Brasileira de Medicina Veterinaria, 38(Supl.1):131-138, 2016. Programa de Pos-Graduacao Ciencia Animal nos Tro- picos, Universidade Federal da Bahia, Av. Adhemar de Barros, 500, Ondina, Salvador, BA, 40170110, Brasil. E-mail: alestrela@gmail.com Canine mammary tumors are frequent in veterinary medical routine, leading to death due to high malignancy rate. Different chemotherapy modalities show large potential on treatment of mammary tumors, mainly improving quality of life. The objective of this report was present and discuss a conventional and metronomic chemotherapy in treatment of advanced stage of canine carcinoma in mixed tumor in femele dog with nine in canine female, nine years old, SRD, attended at the Veterinary Medicine Hospital of the Universidade Federal da Bahia. For this, were described in detail the data of clinical, anatomical and histological, Immune-histochemical and therapeutic therapeutic reports. Chemotherapy with carboplatin, at a dose of 300 mg/m² was not sufficiently effective on controlling metastatic progression, indicating the necessity of new protocols. Chemotherapy with carboplatin, at a dose of 300 mg/m² was not sufficiently effective on controlling metastatic progression, indicating the necessity of new protocols. So, metronomic chemotherapy has been shown excellent results, probably due to control of angiogenesis. Necroscopic and tomography findings were similars. This work also highlights the importance of a long time clinical monitoring of oncologic patients after surgery, in order to detect distant metastasis earlier.