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Spermidine in health and disease

2018; American Association for the Advancement of Science; Volume: 359; Issue: 6374 Linguagem: Inglês

10.1126/science.aan2788

1095-9203

Frank Madeo, Tobias Eisenberg, Federico Pietrocola, Guido Kroemer,

Cannabis and Cannabinoid Research

Having your longevity and eating too Although caloric restriction has clear benefits for maximizing health span and life span, it is sufficiently unpleasant that few humans stick to it. Madeo et al. review evidence that increased intake of the polyamine spermidine appears to reproduce many of the healthful effects of caloric restriction, and they explain its cellular actions, which include enhancement of autophagy and protein deacetylation. Spermidine is found in foods such as wheat germ, soybeans, nuts, and some fruits and vegetables and produced by the microbiota. Increased uptake of spermidine has protective effects against cancer, metabolic disease, heart disease, and neurodegeneration. Science , this issue p. eaan2788