A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow
2018; American Association for the Advancement of Science; Volume: 359; Issue: 6374 Linguagem: Inglês
10.1126/science.aap9112
ISSN1095-9203
AutoresDamith Perera, Joseph W. Tucker, Shalini Brahmbhatt, Christopher J. Helal, Ashley Chong, William Farrell, Paul Richardson, Neal W. Sach,
Tópico(s)Analytical Chemistry and Chromatography
ResumoA reaction screen in flowing solvent Chemists charged with manufacturing pharmaceuticals have recently been exploring the efficiency advantages of continuous flow techniques. Perera et al. now show that a flow apparatus can also accelerate reaction optimization earlier in the drug discovery process. They modified a high-performance liquid chromatography system to screen a wide variety of solvent, ligand, and base combinations to optimize carbon-carbon bond formation. Injecting stock solution aliquots of the catalyst and reactants into a carrier solvent stream let the authors vary the main solvent efficiently and scale up the optimal conditions for product isolation. Science , this issue p. 429
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