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Synthesis of a Glibenclamide Cocrystal: Full Spectroscopic and Thermal Characterization

2018; Elsevier BV; Volume: 107; Issue: 6 Linguagem: Inglês

10.1016/j.xphs.2018.01.029

1520-6017

Silvério Ferreira Silva Filho, Andreia Cardoso Pereira, J. M. G. Sarraguça, Mafalda C. Sarraguça, João A. Lopes, P.F. Façanha Filho, Adenílson O. dos Santos, Paulo Roberto da Silva Ribeiro,

Chemical Thermodynamics and Molecular Structure

A cocrystal of glibenclamide, an antidiabetic drug classified as type II compound according to the Biopharmaceutics Classification System, has been synthesized using tromethamine as coformer in 1:1 molar ratio, by slow solvent evaporation cocrystalization. The cocrystal obtained was characterized by X-ray powder diffraction, differential scanning calorimetry, Raman, mid infrared, and near-infrared spectroscopy. The results consistently show the formation of a cocrystal between active pharmaceutical ingredients and conformer with the synthons corresponding to hydrogen bonding between hydrogen in amines of tromethamine and carbonyl and sulfonyl groups in glibenclamide.