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Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria

2018; American Association for the Advancement of Science; Volume: 359; Issue: 6375 Linguagem: Inglês

10.1126/science.aah3648

1095-9203

Christine M. Dejea, Payam Fathi, John M. Craig, Annemarie Boleij, Rahwa Taddese, Abby L. Geis, Xinqun Wu, Christina E. DeStefano Shields, Elizabeth M. Hechenbleikner, David L. Huso, Robert A. Anders, Francis M. Giardiello, Elizabeth C. Wick, Hao Wang, Shaoguang Wu, Drew M. Pardoll, Franck Housseau, Cynthia L. Sears,

Helicobacter pylori-related gastroenterology studies

Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of