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How patient participation was used to develop a questionnaire that is fit for purpose for assessing quality of life in severe asthma

2018; BioMed Central; Volume: 16; Issue: 1 Linguagem: Inglês

10.1186/s12955-018-0851-9

1477-7525

Michael E. Hyland, Joseph W. Lanario, Jillian Pooler, Matthew Masoli, Rupert Jones,

Delphi Technique in Research

Previous research shows that existing asthma quality of life questionnaires fail to measure the burden of oral corticosteroids that can be used to treat severe asthma, and are therefore not fit for purpose for severe asthma according to the USA's Federal Drug Authority's (FDA) criteria for content validity. Patient input and documentation of that input is key to achieving content validity according to FDA guidelines. This paper describes the process of constructing a new questionnaire to measure the burden of asthma symptoms and burden of treatment in severe asthma, using criteria specified by the FDA.