Portal de Periódicos da CAPES

Eosinophilic esophagitis and symptoms possibly related to eosinophilic esophagitis in oral immunotherapy

2018; Elsevier BV; Volume: 120; Issue: 3 Linguagem: Inglês

10.1016/j.anai.2017.11.016

1534-4436

Daniel Petroni, Jonathan M. Spergel,

Asthma and respiratory diseases

Food allergy is seen in 2% to 8% of the US population and continues to increase. 1 Gupta R.S. Springston E.E. Warrier M.R. et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011; 128: e9-e17 Crossref PubMed Scopus (460) Google Scholar , 2 Sicherer S.H. Munoz-Furlong A. Godbold J.H. Sampson H.A. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol. 2010; 125: 1322-1326 Abstract Full Text Full Text PDF PubMed Scopus (453) Google Scholar , 3 Chafen J.J. Newberry S.J. Riedl M.A. et al. Diagnosing and managing common food allergies: a systematic review. JAMA. 2010; 303: 1848-1856 Crossref PubMed Scopus (246) Google Scholar Patients with food allergy often have an impaired quality of life and may experience nutritional deficiencies. 4 Walkner M. Warren C. Gupta R.S. Quality of life in food allergy patients and their families. Pediatr Clin North Am. 2015; 62: 1453-1461 Abstract Full Text Full Text PDF PubMed Google Scholar , 5 Wood R.A. Food allergen immunotherapy: current status and prospects for the future. J Allergy Clin Immunol. 2016; 137: 973-982 Abstract Full Text Full Text PDF PubMed Scopus (47) Google Scholar Currently, there are no US Food and Drug Administration–approved treatments for food allergy, and it is recommended that patients practice allergen avoidance and carry epinephrine for use in case of severe reaction to unintentional allergen exposure. [6] Boyce J.A. Assa'ad A. Burks A.W. et al. Guidelines for the diagnosis and management of food allergy in the United States: summary of the NIAID-sponsored Expert Panel Report. J Allergy Clin Immunol. 2010; 126: 1105-1118 Abstract Full Text Full Text PDF PubMed Scopus (543) Google Scholar The lifestyle of allergen avoidance presents a challenge and often causes anxiety for patients and caregivers. 4 Walkner M. Warren C. Gupta R.S. Quality of life in food allergy patients and their families. Pediatr Clin North Am. 2015; 62: 1453-1461 Abstract Full Text Full Text PDF PubMed Google Scholar , 7 Marchisotto M.J. Harada L. Blumenstock J.A. et al. Global perceptions of food allergy thresholds in 16 countries. Allergy. 2016; 71: 1081-1085 Crossref PubMed Scopus (5) Google Scholar Oral immunotherapy (OIT) is currently being investigated as a treatment for food allergy. OIT involves consuming the food allergen in gradually increasing doses. 8 Burbank A.J. Burks W. Food specific oral immunotherapy: a potential treatment for food allergy. Expert Rev Gastroenterol Hepatol. 2015; 9: 1147-1159 Crossref PubMed Google Scholar , 9 Hofmann A.M. Scurlock A.M. Jones S.M. et al. Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol. 2009; 124 (e281-286): 286-291 Abstract Full Text Full Text PDF PubMed Scopus (173) Google Scholar Although protocols vary, OIT generally begins with an initial escalation phase, which is conducted under observation in a controlled setting (eg, a clinic or hospital). This is followed by a build-up phase of several weeks or months, during which doses given at home are interspersed with incremental escalation doses given under supervision at a clinic. The final phase is a maintenance phase. 8 Burbank A.J. Burks W. Food specific oral immunotherapy: a potential treatment for food allergy. Expert Rev Gastroenterol Hepatol. 2015; 9: 1147-1159 Crossref PubMed Google Scholar , 9 Hofmann A.M. Scurlock A.M. Jones S.M. et al. Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol. 2009; 124 (e281-286): 286-291 Abstract Full Text Full Text PDF PubMed Scopus (173) Google Scholar