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Rapid flow in multilayer microfluidic paper-based analytical devices

2018; Royal Society of Chemistry; Volume: 18; Issue: 5 Linguagem: Inglês

10.1039/c7lc01300k

1473-0197

Robert B. Channon, Michael Nguyen, Alexis G. Scorzelli, Elijah M. Henry, John Volckens, David S. Dandy, Charles S. Henry,

Electrowetting and Microfluidic Technologies

Microfluidic paper-based analytical devices (μPADs) are a versatile and inexpensive point-of-care (POC) technology, but their widespread adoption has been limited by slow flow rates and the inability to carry out complex in field analytical measurements. In the present work, we investigate multilayer μPADs as a means to generate enhanced flow rates within self-pumping paper devices. Through optical and electrochemical measurements, the fluid dynamics are investigated and compared to established flow theories within μPADs. We demonstrate a ∼145-fold increase in flow rate (velocity = 1.56 cm s